Nonenzymatic autocatalysis generates coacervates and controls their structure.
Mihoubi F. Z., Nakashima K., Bonfio C. Chem (2023), 9, 3394-3396.
I didn’t want to just know the names of things. I remember really wanting to know how it all worked.
Publications
All
Supramolecular biochemistry
Systems biochemistry
Past research and collaborations
Ring opening of glycerol cyclic phosphates leads to a diverse array of potentially prebiotic phospholipids
Aleksandrova M., Rahmatova F., Russell D. A., Bonfio C.* Journal of the American Chemical Society (2023), 145, 25614-25620.
Interfacing coacervates with membranes: from artificial organelles and hybrid protocells to intracellular delivery.
Lu T., Javed S., Bonfio C., Spruijt E. Small Methods (2023), 2300294.
Bioenergetics of early life
Aleksandrova M., Bonfio C.* EMBO Reports (2022), e55679.
A possible path towards encoded protein synthesis on ancient Earth
Bonfio C.* Nature (2022), 605, 231-232, News&Views.
Thermally driven membrane phase transitions enable content reshuffling in primitive cells
Rubio-Sanchez R., Wang A., O’Flaherty D., Coscia F., Petris G., Di Michele L., Cicuta P., Bonfio C.* Journal of the American Chemical Society (2021), 143, 16589-16598.
The curious case of peptide-coordinated iron–sulfur clusters: prebiotic and biomimetic insights
Bonfio C.* Dalton Transactions (2021), 50, 801-807.
Choroid plexus organoids predict CNS drug permeability and reveal human CSF proteins produced by specialised cell types.
Pellegrini L., Bonfio C., Chadwick J., Begum F., Skehel M., Lancaster M. Science (2020), 369, eaaz5626.
Activation chemistry drives the emergence of functionalised protocells.
Bonfio C.*§, Russell D. A.§, Green N. J., Mariani A., Sutherland J. D. Chemical Science (2020), 11, 10688-10697.
Harnessing chemical energy for the activation and joining of prebiotic building blocks.
Liu Z., Wu L., Xu J., Bonfio C., Russell D. A., Sutherland J. D. Nature Chemistry (2020), 12, 1023-1028.
Glycerol configurations of environmental GDGTs investigated using a selective sn2 ether cleavage protocol.
Liu X., Russell D. A., Bonfio C., Summons R. E. Organic Geochemistry (2019), 128, 57-62.
Length-selective synthesis of diacylglycerol-phosphates through energy-dissipative cycling.
Bonfio C.§, Caumes C.§, Duffy C.C.§, Patel B. H.§, Percivalle C.§, Tsanakopoulou M.§, Sutherland J.D. Journal of the American Chemical Society (2019), 141, 3934-3939.
Investigation of glutathione-derived electrostatic and hydrogen bonding interactions and their role in defining Grx5 [2Fe-2S] cluster stability, optical spectra and transfer chemistry.
Sen S., Bonfio C., Mansy S. S., Cowan J. A. Journal of Biological Inorganic Chemistry (2018), 23 (2), 241-252.
pH-driven RNA strand separation under prebiotically plausible conditions.
Mariani A., Bonfio C., Johnson C., Sutherland J. D. Biochemistry (2018), 57, 6382-6386.
Prebiotic iron-sulfur peptide catalysts generate a pH gradient across model membranes of late protocells.
Bonfio C., Godino E., Corsini M., Fabrizi De Biani F., Guella G., Mansy S. S. Nature Catalysis (2018), 1, 616-623.
UV light-driven prebiotic synthesis of iron-sulfur clusters.
Bonfio C., Valer L., Scintilla S., Shah S., Evans D. J., Jin L., Szostak J. W., Sasselov D. D., Sutherland J. D., Mansy S. S. Nature Chemistry (2017), 9, 1229-1234.
The chemical roots of iron-sulfur dependent metabolism.
Bonfio C., Mansy S. S. Biochemistry (2017), 56, 5225-5226.
Cysteine containing dipeptides show a metal specificity that matches the composition of seawater.
Belmonte L., Rossetto D., Forlin M., Scintilla S., Bonfio C., Mansy S. S. Physical Chemistry Chemical Physics (2016), 18, 20104-8.
Duplications of an Iron-Sulfur Tripeptide Leads to the Formation of a Protoferredoxin.
Scintilla S., Bonfio C., Belmonte L., Forlin M., Rossetto D., Li J., Cowan J. A., Galliani A., Arnesano F., Assfalg M., Mansy S. S. Chemical Communications (2016), 52, 13456-13459.
Nonenzymatic autocatalysis generates coacervates and controls their structure.
Mihoubi F. Z., Nakashima K., Bonfio C. Chem (2023), 9, 3394-3396.
Thermally driven membrane phase transitions enable content reshuffling in primitive cells
Rubio-Sanchez R., Wang A., O’Flaherty D., Coscia F., Petris G., Di Michele L., Cicuta P., Bonfio C.* Journal of the American Chemical Society (2021), 143, 16589-16598.
Length-selective synthesis of diacylglycerol-phosphates through energy-dissipative cycling.
Bonfio C.§, Caumes C.§, Duffy C.C.§, Patel B. H.§, Percivalle C.§, Tsanakopoulou M.§, Sutherland J.D. Journal of the American Chemical Society (2019), 141, 3934-3939.
Ring opening of glycerol cyclic phosphates leads to a diverse array of potentially prebiotic phospholipids
Aleksandrova M., Rahmatova F., Russell D. A., Bonfio C.* Journal of the American Chemical Society (2023), 145, 25614-25620.
Bioenergetics of early life
Aleksandrova M., Bonfio C.* EMBO Reports (2022), e55679.
A possible path towards encoded protein synthesis on ancient Earth
Bonfio C.* Nature (2022), 605, 231-232, News&Views.
Activation chemistry drives the emergence of functionalised protocells.
Bonfio C.*§, Russell D. A.§, Green N. J., Mariani A., Sutherland J. D. Chemical Science (2020), 11, 10688-10697.
Harnessing chemical energy for the activation and joining of prebiotic building blocks.
Liu Z., Wu L., Xu J., Bonfio C., Russell D. A., Sutherland J. D. Nature Chemistry (2020), 12, 1023-1028.
Interfacing coacervates with membranes: from artificial organelles and hybrid protocells to intracellular delivery.
Lu T., Javed S., Bonfio C., Spruijt E. Small Methods (2023), 2300294.
The curious case of peptide-coordinated iron–sulfur clusters: prebiotic and biomimetic insights
Bonfio C.* Dalton Transactions (2021), 50, 801-807.
Choroid plexus organoids predict CNS drug permeability and reveal human CSF proteins produced by specialised cell types.
Pellegrini L., Bonfio C., Chadwick J., Begum F., Skehel M., Lancaster M. Science (2020), 369, eaaz5626.
Glycerol configurations of environmental GDGTs investigated using a selective sn2 ether cleavage protocol.
Liu X., Russell D. A., Bonfio C., Summons R. E. Organic Geochemistry (2019), 128, 57-62.
Investigation of glutathione-derived electrostatic and hydrogen bonding interactions and their role in defining Grx5 [2Fe-2S] cluster stability, optical spectra and transfer chemistry.
Sen S., Bonfio C., Mansy S. S., Cowan J. A. Journal of Biological Inorganic Chemistry (2018), 23 (2), 241-252.
pH-driven RNA strand separation under prebiotically plausible conditions.
Mariani A., Bonfio C., Johnson C., Sutherland J. D. Biochemistry (2018), 57, 6382-6386.
Prebiotic iron-sulfur peptide catalysts generate a pH gradient across model membranes of late protocells.
Bonfio C., Godino E., Corsini M., Fabrizi De Biani F., Guella G., Mansy S. S. Nature Catalysis (2018), 1, 616-623.
UV light-driven prebiotic synthesis of iron-sulfur clusters.
Bonfio C., Valer L., Scintilla S., Shah S., Evans D. J., Jin L., Szostak J. W., Sasselov D. D., Sutherland J. D., Mansy S. S. Nature Chemistry (2017), 9, 1229-1234.
The chemical roots of iron-sulfur dependent metabolism.
Bonfio C., Mansy S. S. Biochemistry (2017), 56, 5225-5226.
Cysteine containing dipeptides show a metal specificity that matches the composition of seawater.
Belmonte L., Rossetto D., Forlin M., Scintilla S., Bonfio C., Mansy S. S. Physical Chemistry Chemical Physics (2016), 18, 20104-8.
Duplications of an Iron-Sulfur Tripeptide Leads to the Formation of a Protoferredoxin.
Scintilla S., Bonfio C., Belmonte L., Forlin M., Rossetto D., Li J., Cowan J. A., Galliani A., Arnesano F., Assfalg M., Mansy S. S. Chemical Communications (2016), 52, 13456-13459.
* indicates the corresponding author
§ indicates co-first author(s)